Patent Acquired for Off-Target Risk Analysis Method and System
06.07.2026
PtBio Group, in collaboration with Hiroshima University, has acquired a patent for an off-target risk analysis method, an off-target risk analysis system, a program, and a recording medium in genome editing.
"DOLPHiN" is our proprietary off-target risk analysis simulation system powered by this patented technology. It is a state-of-the-art analysis system designed to ensure the safety of genome editing tools.
This achievement is a research outcome of the R&D project "Development of a Digitally Driven End-to-End Genome Editing Platform for Industrial Applications" under the COI-NEXT "The Center of Innovation
for Bio-Digital Transformation (Bio-DX)," in which our company is a participant.
Conventional methods generally predicted off-target events by cross-referencing with the entire genomic information (reference genome) of the target organism into which genome editing is to be introduced. However, a major feature of this newly patented technology is its ability to predict the likelihood of potential risks based solely on the information of the pre-set "target sequence itself."
This allows for the accurate filtering of high-risk targets during primary screening. Utilizing a unique algorithm, the system can quantify and select safe target sequences that are highly unlikely to cause off-targets, regardless of the organism's genome.
We expect this technology to be highly valuable in the following scenarios:
When conducting genome editing on organisms whose whole-genome information is unmapped or not yet fully understood, or when looking to easily assess the risks of a designed target.
When the actual genome structure significantly diverges from the reference genome due to individual differences, and there is a need to design potentially safe targets.
Through the provision of this technology, PtBio aims to simultaneously reduce analysis costs and maximize safety in industrial genome editing. We remain committed to contributing to the sustainable development of the bio-industry utilizing a wide diversity of organisms.
■ Patent Overview
Patent Number: Patent No. 7878661
Invention Title: Off-Target Risk Analysis Method, Off-Target Risk Analysis System, Program, and Recording Medium
Registration Date: June 15, 2026
